Marty
Marty is a GMP grade cell manufacturing system we are developing using the same core architecture as Emmet. Protocols you develop on Emmet can seamlessly be transferred to Marty for closed, automated and scalable cell manufacture.
Conserve scarce resources
Decouple your cell manufacturing from variable manual processes and create viable unit economics for your asset's mass market manufacture.
Create consistent protocols
Quantify and automate mechanical, environmental and bioprocess conditions to maintain unparalleled control over your processes.
Gain actionable insights
In-line sensing and machine intelligence driven control systems turn the black box nature of conventional cell culture into your optimisation playground.
Fit your process
Use Marty as a standalone cell manufacturing system or integrate it with other instruments in your manufacturing process.
It's time to industrialize your cell manufacturing
Reduce manual labour
Use 80%+ less labour for your cell manufacturing processes
Robust protocols
>50%+ fewer process failures than manual cell manufacturing methods
Save time
Remove tedious tech transfers and develop GXP bioprocesses in <6 months on Marty
Marty closes, automates and scales your processes
Cell manufacturing
With Marty, you can develop standardised, robust, and reliably scalable expansion protocols to reduce process variability and save hands-on time. Automate every step of your cell culture workflow in a single closed and automated system.
Differentiation
With Marty, you can develop robust differentiation processes that readily translate to bioproduction environments. Reduce points for human error and maintain consistent cell culture micro-environments that linearly scale from discovery to commercial production.
Real-time insight
Monitor the quality attributes critical to your process with in-line metabolic sensing. We're currently developing and implementing an adaptive process control systems for Marty which optimizes processes for CQA's in real time, automatically. Reach out if you want to know more.
Say goodbye to tube welding
Our proprietary sterile connection systems can make, break and re-form sterile fluid connection pathways. Reducing points of contamination, and saving time when translating to a GMP process.
Control and scale your processes
Define each step of your process in our customizable protocol builder. Digitised protocols can be transferred seamlessly between systems to facilitate scale up.
Frequently asked questions
Marty is a single-instrument, closed and fully automated cell manufacturing solution.
Marty leverages fluidics, mechanical actuation and environmental controls, in-line biochemical based sensing and machine intelligence driven adaptive process control systems.
Marty combines a gas and temperature-controlled incubator where cell culture occurs, with a refrigerated on-board reagent storage unit. A fluid manifold then connects a series of parallelised “plug and play” cell culture vessels in the incubated section. With reagents from the reagent storage section, as well as mixers, waste reagent storage, and other subsystems necessary to complete cell culture workflows.
This enables point-to-point movement from almost any input/output within Marty. From reagent storage to mixing chamber (e.g. to pre-warm media before perfusing into a cell culture vessel), cell culture vessel to cell culture vessel, via intermediary chambers (e.g. for passaging cells) and cell culture vessel to external receptacles (e.g. for removing waste supernatent or harvesting cell suspension). Cell culture vessels are machine-actuated to provide homogenous fluid distribution and gas diffusion.
We have begun implementing in-line and off-line metabolic sensors. These include the standard pH and dissolved gasses (CO2, O2). As well as novel analytical methods and sensor designs we are developing in-house to provide real time insight into key process parameters. Finally, we are developing a machine intelligence based adaptive process control system. That is able to take data from in-line sensors and climate control sensors in real time and generate proposed process actions that either a human-in-the-loop, or Marty, can decide to implement.
Marty scales "up and out," providing a flexible option to scale production to meet demand. This means you (as a therapeutic developer) don't need necessarily need a CDMO partner to develop a bioprocess. You can develop your bioprocess right in your labs without having to purchase a multi-million dollar suite of equipment (we have no ill will towards CDMOs and are happy to speak with you as well!)
Marty uses a series of parallelized “plug and play” cell culture vessels that scale "up and out." The aim is to have you develop a process on one our culture cartridges. Then, “scale up” to multiple vessels within Marty. Before “scaling out” to running multiple Marty systems in parallel.
Marty's approach not only simplifies the tech transfer process but also saves you valuable time. It eliminates the need to adapt your cells and process into formats for which the biology was not designed, providing a more straightforward and faster way to get regulatory approval and bring your innovations to market.
However, if you would prefer a CDMO partnership to adapt your therapeutic candidate to a GXP process on Marty, please reach out to us, and we will let you know when our first process development and manufacturing facilities are online.
We’ve demonstrated that Marty can reliably expand iPSCs and generate differentiated progeny.
Marty is able to culture any anchorage-dependent cell line or protocol (e.g. MSCs, ES, Primary Cells, Cell lines etc.).
If you are working with suspension-based cell lines, particularly HSCs, T cells, NK cells, TILs, or TRegs, we welcome the opportunity to speak and learn more about you and your challenges.
Both. Please reach out if you'd like walk through your process map and see if Marty is a good fit for your cells and process aims.
Yes. Most any anchorage-dependent processes should be adaptable to Marty.
We have demonstrated some suspension-adapted processes in Marty. This is an area of active development. If you are working with a manual or difficult-to-automate suspension-based process, we welcome the chance to speak with you to explore how Marty could help you and your teams out.
A challenge we encountered when developing Marty was how time-consuming and resource-inefficient tube welding, and sterile connection forming in general, is.
In line with our broader thesis that scientists shouldn't spend half their days moving liquids between plastic containers. We believe that human beings shouldn’t have to spend hours of their days making, breaking and re-forming connections between plastic tubes.
That’s why we developed our patent pending method to form sterile fluidic paths that we've automated to turn a 30-minute (avg. time to do & check a tube weld) process into a < 30-second process (avg. time for automated sterile connection formation). If you want to see sterility testing data or learn more about our sterile connector system, please reach out.
Currently, data Marty generates (e.g., sensor data, information of process parameters, process actions, etc.) is all stored locally or on an external cloud-based data storage system. On our roadmap, we plan to implement electronic batch records to integrate with your LIMS and eQMS systems.
We are working towards demonstrating Marty in a GMP-compliant cell manufacturing process.
